According to wobble hypothesis, allowed base pairings are given in table 7. 5: due to the wobble base pairing one trna becomes able to recognise more than one codons for an individual amino acid. clc business plan. wobble or fluctuating base: crickproposed wobble hypothesis. according to this hypothesis, the base in first position of anti- codon on trna is usually an abnormal base, like inosine, pseudouridine, tyrosine etc. these abnormal bases are able to pair with more than one type of nitrogenous base in the third position of the codon on mrna. the wobble hypothesis. the wobble hypothesis states that the base at 5' end of the anticodon is not spatially confined as the other two bases allowing it to form hydrogen bonds with any of several bases located at the 3' end of a codon. a theory to explain the partial degeneracy of the genetic code due to the fact that some t- rna molecules can recognize more than one codon. the theory proposes that the first two bases in the codon and anticodon will form complementary pairs in the normal antiparallel fashion. definition of wobble hypothesis in the medical dictionary by the free dictionary.
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these notions led francis crick to the creation of the wobble hypothesis, a set of four relationships explaining these naturally occurring attributes.
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one trna molecule ( with one amino acid attached) can recognise and bind to more than one codon, due to the less- precise base pairs that can arise between the 3rd base of the codon and the base at the 1st position on the anticodon. the u at the wobble position will be able to pair with an adenine or a guanine.